Is there anywhere to buy a six pack around 2nd and South Street?

Wooly Mammoth on south and passyunk (between 4th and 5th).
They have everything from local beer to imports, as well as the popular brands.

You can also get sixpacks at manny browns. on south between 5th and sixth, but wooly mammoth has a larger collection.

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Paddy Whacks -- I don't know how extensive the selection is, but I get 6 packs of Yuengling there regularly.